As seen in Amazing Spider Man

Leather Briefcase Cenzo in the Amazing Spider Man
Floto leather bags have made cameos in Hot Tub Time Machine, The Hunter, Ocean's Thirteen, Definitley Maybe, but the biggest role was given to our Cenzo Brief in The Amazing Spider Man as Dr. Richard Parkers long lost leather bag.  The information found inside a secret pocket in the bag sends Peter on a quest to discover the truth behind the disappearance of his parents, and eventually leads to his transformation into Spider-Man!